Henderson B, Blake S
Maxillofacial Surgery and Oral Medicine Research Unit, University of London, Eastman Dental Hospital, UK.
Trends Pharmacol Sci. 1992 Apr;13(4):145-52. doi: 10.1016/0165-6147(92)90052-8.
Interleukin 1 is just one of a large, growing, collection of potent cytokines that are produced by a variety of cells and have a myriad of overlapping activities. Many of these cytokines have important pathophysiological actions in diseases ranging from rheumatoid arthritis to AIDS. Selective inhibition of the synthesis or of the action of specific cytokines may have therapeutic benefit. In this review, Brian Henderson and Simon Blake discuss the ways in which cytokine function could be manipulated pharmacologically for therapeutic benefit.
白细胞介素1只是众多强大的细胞因子中的一种，这类细胞因子的数量还在不断增加，由多种细胞产生，具有无数重叠的活性。其中许多细胞因子在从类风湿性关节炎到艾滋病等多种疾病中都具有重要的病理生理作用。选择性抑制特定细胞因子的合成或作用可能具有治疗益处。在这篇综述中，布莱恩·亨德森和西蒙·布莱克讨论了通过药理学手段操纵细胞因子功能以获得治疗益处的方法。
