Cosar Sumru, Oktar Suna O, Cosar Behcet, Yücel Cem, Ozdemir Hakan
Department of Radiology, Ankara Oncology Hospital, 38. Cad. 5/15, Cukurambar, Demetevler-Ankara 06200, Turkey.
Eur J Radiol. 2005 Jun;54(3):393-9. doi: 10.1016/j.ejrad.2004.07.015.
The aim of this study is to search sonographically for morphological and hemodynamic changes in hepatic and splanchnic vasculature of alcoholic patients having no signs of hepatic damage, and compare these with normal healthy subjects.
Thirty alcohol-dependent patients and 30 control subjects with no alcohol problem or hepatic impairment were included in the study. All patients were evaluated by gray-scale and spectral Doppler ultrasound. The diameter of the portal vein, portal venous velocity, peak systolic and end diastolic velocities of hepatic and superior mesenteric arteries were assessed. RI, PI and systolic/diastolic velocity ratios were also calculated.
Portal vein cross-sectional area was greater in alcoholic patients compared to control group (P = 0.0012). Portal vein velocity, hepatic artery peak systolic and end diastolic velocity, superior mesenteric artery peak systolic and end diastolic velocity were significantly greater in alcoholic patients than in control group (P < or = 0.001). No statistically significant difference was detected between other parameters evaluated.
In alcohol-dependent patients, some hemodynamic and morphologic changes occur in hepatic and splanchnic circulation, even before the signs of hepatic damage develop. These changes can be detected by means of Doppler and gray-scale sonogrsphy.
本研究旨在通过超声检查寻找无肝损伤迹象的酒精性患者肝脏和内脏血管系统的形态学及血流动力学变化，并与正常健康受试者进行比较。
本研究纳入了30名酒精依赖患者和30名无酒精问题或肝损伤的对照受试者。所有患者均接受了灰阶和频谱多普勒超声检查。评估门静脉直径、门静脉流速、肝动脉和肠系膜上动脉的收缩期峰值流速及舒张末期流速。还计算了阻力指数（RI）、搏动指数（PI）和收缩期/舒张期流速比值。
与对照组相比，酒精性患者的门静脉横截面积更大（P = 0.0012）。酒精性患者的门静脉流速、肝动脉收缩期峰值和舒张末期流速、肠系膜上动脉收缩期峰值和舒张末期流速均显著高于对照组（P≤0.001）。在评估的其他参数之间未检测到统计学上的显著差异。
在酒精依赖患者中，即使在肝损伤迹象出现之前，肝脏和内脏循环中也会发生一些血流动力学和形态学变化。这些变化可通过多普勒和灰阶超声检查检测到。
