Arvela Riina K, Leadbeater Nicholas E
Department of Chemistry, University of Connecticut, Unit 3060, 55 North Eagleville Road, Storrs, Connecticut 06269-3060, USA.
Org Lett. 2005 May 26;7(11):2101-4. doi: 10.1021/ol0503384.
[reaction: see text]. We present here a methodology for the Suzuki coupling of aryl chlorides with phenylboronic acid using Pd/C as a catalyst, water as a solvent, and microwave heating. We show that simultaneous cooling in conjunction with microwave heating prolongs the lifetime of the aryl chloride substrates during the course of the reaction and, as a result, yields of the desired biaryl as well as overall recovery of material can be increased.
[反应：见正文]。我们在此展示一种使用钯/碳作为催化剂、水作为溶剂并采用微波加热的方法，用于芳基氯与苯基硼酸的铃木偶联反应。我们表明，在微波加热的同时进行冷却可延长芳基氯底物在反应过程中的寿命，结果是所需联芳基的产率以及材料的总回收率都能提高。
