通过氧硫磷杂环戊烷方法合成核苷α-硫代三磷酸酯。
Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach.
作者信息
Misiura Konrad, Szymanowicz Daria, Stec Wojciech J
机构信息
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland.
出版信息
Org Lett. 2005 May 26;7(11):2217-20. doi: 10.1021/ol050617r.
PMID:15901173
Abstract
[reaction: see text]. Nucleoside 5'-O-(alpha-thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5'-O-(2-thio-1,3,2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of alpha-seleno congeners and corresponding alpha-modified diphosphates.
摘要
[反应：见正文]。在DBU存在下，适当的核苷5'-O-(2-硫代-1,3,2-氧硫磷杂环戊烷)与焦磷酸反应，得到核苷5'-O-(α-硫代三磷酸酯)。所提出的方法也可用于制备α-硒代类似物和相应的α-修饰二磷酸酯。
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