Stec W J
Polish Academy of Sciences, Department of Bioorganic Chemistry, Lódź.
Nucleic Acids Symp Ser. 1991(25):171-2.
The syntheses of 5'-O-DMT base-protected nucleoside 3'-O-[2-thio-1.3.2-oxathia-phospholanes] (1) and their subsequent reactions with nucleosides bound via 3'-oxygen to solid support, performed in the presence of DBU, formulate the basis to new methodology of preparation of title compounds--OligoS. Moreover separation of 1 into diastereoisomeric species allows the preparation of OligoS in stereocontrolled manner.
5'-O-DMT碱基保护的核苷3'-O-[2-硫代-1,3,2-氧杂硫磷杂环戊烷]（1）的合成及其随后在DBU存在下与通过3'-氧连接到固体支持物上的核苷的反应，为制备标题化合物——寡核苷酸（OligoS）的新方法奠定了基础。此外，将1分离为非对映异构体可实现以立体控制的方式制备寡核苷酸（OligoS）。
