Motozaki Toru, Sawamura Kiyoto, Suzuki Akari, Yoshida Keigo, Ueki Tatsuo, Ohara Aiko, Munakata Ryosuke, Takao Ken-Ichi, Tadano Kin-Ichi
Department of Applied Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.
Org Lett. 2005 May 26;7(11):2265-7. doi: 10.1021/ol050763x.
[reaction: see text]. We have completed the total synthesis of natural (+)-tubelactomicin A (1), a 16-membered macrolide antibiotic. This Letter presents a highly efficient synthesis of the upper-half segment (C14-C24) and the completion of the total synthesis featuring a high-yielding Stille coupling for the connection of the upper-half and lower-half segments and Mukaiyama macrolactonization for the construction of the entire structure of 1.
[反应：见正文]。我们已经完成了天然（+）-管乳菌素A（1）的全合成，它是一种16元大环内酯类抗生素。本信函介绍了上半段（C14 - C24）的高效合成方法，以及全合成的完成情况，该全合成以用于连接上半段和下半段的高产率Stille偶联反应以及用于构建1的整个结构的Mukaiyama大环内酯化反应为特色。
