地衣大环内酯（+）-曲霉青霉素的简洁全合成
A concise total synthesis of the lichen macrolide (+)-aspicilin.
作者信息
Dubost Christophe, Markó Istvan E, Ryckmans Thomas
机构信息
Université Catholique de Louvain, Département de Chimie, 1 Place Louis Pasteur, B-1348 Louvain La Neuve, Belgium.
出版信息
Org Lett. 2006 Oct 26;8(22):5137-40. doi: 10.1021/ol0620287.
PMID:17048862
Abstract
The total synthesis of the polyhydroxylated macrolide (+)-aspicilin 5 is described using as a key step a highly diastereoselective allylation of aldehyde 6 with the uniquely functionalized allylstannane 1. (+)-Aspicilin is obtained in 18 steps and 10% overall yield. [structure: see text]
摘要
报道了多羟基大环内酯（+）-阿西西林5的全合成，其关键步骤是醛6与具有独特官能化的烯丙基锡烷1进行高度非对映选择性烯丙基化反应。（+）-阿西西林经过18步反应得到，总收率为10%。[结构：见原文]
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