Lievens Sarah C, Molinski Tadeusz F
Department of Chemistry, University of California, Davis, California 95616, USA.
Org Lett. 2005 May 26;7(11):2281-4. doi: 10.1021/ol050717x.
[structure: see text]. An unidentified tunicate from Pohnpei, Micronesia, yielded sagittamides A and B-compounds comprising a long-chain C26 dicarboxylic acid that acylates terminal L-valine and L-ornithine groups. The structures, which contain an unprecedented internal O-hexacetyl-1,2,3,4,5,6-hexaol moiety, were determined by combined spectroscopic analysis including mass spectrometry and 1D and 2D NMR and chemical degradation. The partial absolute stereochemistry of the new compounds was addressed by Marfey's analysis.
[结构：见正文]。从密克罗尼西亚波纳佩岛采集的一种未鉴定的被囊动物产生了矢车菊酰胺A和B，这些化合物包含一种长链C26二羧酸，该二羧酸酰化末端的L-缬氨酸和L-鸟氨酸基团。其结构包含一个前所未有的内部O-六乙酰基-1,2,3,4,5,6-己醇部分，通过包括质谱、一维和二维核磁共振以及化学降解在内的联合光谱分析确定。新化合物的部分绝对立体化学通过马尔菲分析得以确定。
