来自海洋海鞘独居囊尾海鞘的细胞毒性星形孢菌素。

Cytotoxic staurosporines from the marine ascidian Cystodytes solitus.

作者信息

Reyes Fernando, Fernández Rogelio, Rodríguez Alfredo, Bueno Santiago, de Eguilior Carlos, Francesch Andrés, Cuevas Carmen

机构信息

Medicinal Chemistry Department, PharmaMar S.A.U., Pol. Ind. La Mina Norte, Avenida de los Reyes 1, 28770-Colmenar Viejo, Madrid, Spain.

出版信息

J Nat Prod. 2008 Jun;71(6):1046-8. doi: 10.1021/np700748h. Epub 2008 May 17.

DOI:10.1021/np700748h

PMID:18484775

Abstract

Two new indolocarbazole alkaloids, 7-oxo-3,8,9-trihydroxystaurosporine (1) and 7-oxo-8,9-dihydroxy-4'-N-demethylstaurosporine (2), were isolated from samples of the marine ascidian Cystodytes solitus. Their structures were determined by a combination of spectroscopic techniques, including (+)-HRMALDITOFMS and 1D and 2D NMR spectroscopy, and comparison with published data for related structures. Both compounds displayed strong cytotoxicity against three human tumor cell lines.

摘要

从海洋海鞘孤立囊海鞘（Cystodytes solitus）的样本中分离出两种新的吲哚咔唑生物碱，7-氧代-3,8,9-三羟基星形孢菌素（1）和7-氧代-8,9-二羟基-4'-N-去甲基星形孢菌素（2）。它们的结构通过多种光谱技术确定，包括（+）-高分辨基质辅助激光解吸电离飞行时间质谱以及一维和二维核磁共振光谱，并与相关结构的已发表数据进行比较。这两种化合物对三种人类肿瘤细胞系均表现出强烈的细胞毒性。