Gordts S, Campo R, Puttemans P, Brosens I, Valkenburg M, Norre J, Renier M, Coeman D, Gordts S
Leuven Institute for Fertility and Embryology, Tiensevest 168, 3000 Leuven, Belgium.
Reprod Biomed Online. 2005 Apr;10(4):436-41. doi: 10.1016/s1472-6483(10)60818-8.
In order to reduce the number of multiple pregnancies following IVF, the Belgian government agreed to reimburse laboratory expenses for six IVF cycles up to the age of 42 years, in exchange for restriction of the number of embryos replaced. Data on assisted reproduction outcome before and after the introduction of this new legislation were analysed retrospectively in terms of implantation, pregnancy and multiple pregnancy rates. After the introduction of the new law, the percentage of single embryo transfer increased from 14 to 49%. Implantation rates were 25.9 and 23% respectively. There was no difference in the overall pregnancy rate before and after the introduction (36 versus 37%). Twin pregnancies, however, decreased from 19 to 3%. These findings indicate that elective single embryo transfer significantly decreases the twin pregnancy rate without a reduction in the overall pregnancy rate.
为了减少体外受精（IVF）后多胎妊娠的数量，比利时政府同意报销42岁以下六个IVF周期的实验室费用，以换取限制移植胚胎的数量。对这项新立法实施前后辅助生殖结果的数据，就着床率、妊娠率和多胎妊娠率进行了回顾性分析。新法律实施后，单胚胎移植的比例从14%提高到了49%。着床率分别为25.9%和23%。实施前后的总体妊娠率没有差异（36%对37%）。然而，双胎妊娠从19%降至3%。这些发现表明，选择性单胚胎移植可显著降低双胎妊娠率，而不会降低总体妊娠率。
