Reed Robin, Cheng Hong
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Curr Opin Cell Biol. 2005 Jun;17(3):269-73. doi: 10.1016/j.ceb.2005.04.011.
The machineries involved in gene expression are highly conserved from yeast to metazoans. However, a fundamental difference between these organisms is that most yeast genes lack introns whereas the converse is true in higher organisms. Recent studies of the TREX complex, which functions in mRNA export, unexpectedly revealed that this complex is recruited by the transcription machinery in yeast whereas the TREX complex appears to be recruited by the splicing machinery in mammals. Studies during the past year also revealed a possible conserved role for SR protein dephosphorylation in regulating the interaction between SR proteins and the mRNA export receptor TAP (Mex67 in yeast). There is also an interesting possibility that an SR protein-TREX complex interaction is a conserved part of the mRNA export machinery.
从酵母到后生动物，参与基因表达的机制高度保守。然而，这些生物体之间的一个根本差异在于，大多数酵母基因缺乏内含子，而在高等生物中情况则相反。最近对在mRNA输出过程中发挥作用的TREX复合物的研究意外地发现，该复合物在酵母中是由转录机制招募的，而在哺乳动物中，TREX复合物似乎是由剪接机制招募的。过去一年的研究还揭示了SR蛋白去磷酸化在调节SR蛋白与mRNA输出受体TAP（酵母中的Mex67）之间相互作用方面可能具有保守作用。还有一种有趣的可能性，即SR蛋白与TREX复合物的相互作用是mRNA输出机制中保守的一部分。
