介导戈登氏链球菌血小板结合蛋白GspB输出的附属sec系统的另外两个组分。
Two additional components of the accessory sec system mediating export of the Streptococcus gordonii platelet-binding protein GspB.
作者信息
Takamatsu Daisuke, Bensing Barbara A, Sullam Paul M
机构信息
Department of Medicine, Veterans Affairs Medical Center (111W), 4150 Clement Street, San Francisco, California 94121, USA.
出版信息
J Bacteriol. 2005 Jun;187(11):3878-83. doi: 10.1128/JB.187.11.3878-3883.2005.
Abstract
The gspB-secY2A2 locus of Streptococcus gordonii strain M99 encodes the platelet-binding glycoprotein GspB, along with proteins that mediate its glycosylation and export. We have identified two additional components of the accessory Sec system (Asp4 and Asp5) encoded just downstream of gtfB in the gspB-secY2A2 locus. These proteins are required for GspB export and for normal levels of platelet binding by M99. Asp4 and Asp5 may be functional homologues of SecE and SecG, respectively.
摘要
戈登氏链球菌M99菌株的gspB-secY2A2位点编码血小板结合糖蛋白GspB以及介导其糖基化和输出的蛋白质。我们在gspB-secY2A2位点的gtfB下游鉴定出了辅助Sec系统的另外两个组分（Asp4和Asp5）。这些蛋白质是GspB输出以及M99正常水平的血小板结合所必需的。Asp4和Asp5可能分别是SecE和SecG的功能同源物。
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本文引用的文献
1
The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha.戈登链球菌表面蛋白GspB和Hsa介导与血小板膜糖蛋白Ibalpha上唾液酸化碳水化合物表位的结合。
Infect Immun. 2004 Nov;72(11):6528-37. doi: 10.1128/IAI.72.11.6528-6537.2004.
2
Four proteins encoded in the gspB-secY2A2 operon of Streptococcus gordonii mediate the intracellular glycosylation of the platelet-binding protein GspB.戈登氏链球菌gspB-secY2A2操纵子中编码的四种蛋白质介导血小板结合蛋白GspB的细胞内糖基化。
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Functional analysis of the Streptococcus gordonii DL1 sialic acid-binding adhesin and its essential role in bacterial binding to platelets.戈登氏链球菌DL1唾液酸结合黏附素的功能分析及其在细菌与血小板结合中的重要作用。
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