[库欣综合征与肾上腺腺瘤。两种惊人的关联]
[Cushing's syndrome and adrenal adenoma. Two surprising associations].
作者信息
Ouzounian S, Tissier F, Gouya H, Kujas M, Louvel A, Legmann P, Bertagna X
机构信息
Service des maladies endocriniennes et métaboliques, Hôpital Cochin, Paris.
出版信息
Presse Med. 2005 Apr 9;34(7):511-5. doi: 10.1016/s0755-4982(05)83961-2.
INTRODUCTION
Cushing's syndrome has a very low incidence (1-10 cases/million/year), and familial cases are even more rare. We report on two situations involving different causes of Cushing's syndrome.
CASES
In the first case, we describe the case of a patient with an adrenal adenoma 20 years before the occurrence of Cushing's disease related to the pineal gland. In the second case, two members of the same family were diagnosed almost simultaneously with adrenal cortical adenoma (mother) and Cushing's disease (daughter).
DISCUSSION
These cases lead us to consider the known causes of familial Cushing's syndrome, which were not found here.
引言
库欣综合征的发病率极低（每年每百万人口中有1 - 10例），家族性病例更为罕见。我们报告两例由不同病因引起的库欣综合征病例。
病例
第一例，我们描述了一名患者，其在松果体相关的库欣病发生前20年就患有肾上腺腺瘤。第二例，同一家庭的两名成员几乎同时被诊断为肾上腺皮质腺瘤（母亲）和库欣病（女儿）。
讨论
这些病例促使我们思考家族性库欣综合征的已知病因，而在本病例中未发现这些病因。
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