Vidyasagar D, Lukkarinen H, Kaapa P, Zagariya A
Division of Neonatology, University of Illinois at Chicago, Chicago, Illinois, USA.
Biotechnol Prog. 2005 Jan-Feb;21(1):192-7. doi: 10.1021/bp0497886.
An important feature of meconium-instilled newborn lungs is an inflammatory response and apoptotic cell death. It was recently demonstrated by our group and supported by several other investigators in a relatively short period of time. Apoptosis exists also in healthy lungs, but in meconium-instilled lungs its level is usually dramatically higher. Apoptosis is characterized by loss of cell function, decrease in cell size, and its morphology. Apoptosis plays an important role in normal cell life, but increased levels of apoptosis induce great damage for any tissues. Apoptosis in the lungs has been greatly overlooked for the past decade, and meconium-induced apoptosis is a relatively new event and not effectively studied at the present time. This Review summarized current knowledge regarding meconium-induced inflammation and apoptosis in newborn lungs.
胎粪吸入新生儿肺部的一个重要特征是炎症反应和凋亡性细胞死亡。最近我们小组证明了这一点，并且在相对较短的时间内得到了其他几位研究者的支持。凋亡也存在于健康的肺部，但在胎粪吸入的肺部，其水平通常会显著升高。凋亡的特征是细胞功能丧失、细胞大小减小及其形态变化。凋亡在正常细胞生命中起重要作用，但凋亡水平的升高会对任何组织造成巨大损害。在过去十年中，肺部凋亡一直被严重忽视，而胎粪诱导的凋亡是一个相对较新的现象，目前尚未得到有效研究。本综述总结了目前关于胎粪诱导的新生儿肺部炎症和凋亡的知识。
