Saugstad O D, Tølløfsrud P A, Lindenskov P, Drevon C A
Department of Pediatric Research and Pediatrics, Rikshospitalet Medical Center, University of Oslo, Oslo, Norway.
J Perinatol. 2008 Dec;28 Suppl 3:S113-5. doi: 10.1038/jp.2008.151.
To review and summarize experimental data examining the effects of different fractions of meconium, and to test the effect of albumin on meconium aspiration both as prophylactic and rescue treatment. Newborn piglets 2 to 5 days of age were made hypoxic and then instilled meconium or fractions of meconium intratracheally. Meconium-added albumin and albumin instilled after meconium were also tested. Lung function and inflammatory cytokines were measured. Both the lipid- and water-soluble fractions induce inflammation in the lungs with elevation of inflammatory cytokines. When meconium was mixed with albumin, the inflammatory effects of meconium were significantly ameliorated. Rescue therapy with intratracheal albumin 5 min after the meconium aspiration syndrome was induced also improved lung function. These results indicate that at least part of the symptoms seen in the meconium aspiration syndrome could be prevented by blocking the active substances of meconium such as bile acids and free fatty acids.
回顾并总结研究胎粪不同成分作用的实验数据，以及测试白蛋白作为预防性和抢救性治疗对胎粪吸入的影响。对2至5日龄的新生仔猪进行缺氧处理，然后经气管内注入胎粪或胎粪成分。还测试了添加白蛋白的胎粪以及胎粪注入后注入的白蛋白。测量肺功能和炎性细胞因子。脂溶性和水溶性成分均会导致肺部炎症，炎性细胞因子升高。当胎粪与白蛋白混合时，胎粪的炎症作用会显著改善。在诱导胎粪吸入综合征5分钟后经气管内注入白蛋白进行抢救治疗也可改善肺功能。这些结果表明，通过阻断胎粪中的活性物质如胆汁酸和游离脂肪酸，可至少预防部分胎粪吸入综合征的症状。
