Wong Chi-Huey
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
J Org Chem. 2005 May 27;70(11):4219-25. doi: 10.1021/jo050278f.
Protein glycosylation is the most complex post-translational modification process. More than 50% of proteins in humans are glycosylated, while bacteria such as E. coli does not have this modification machinery. Many small-molecule natural products also require glycosylation in order to express their function. Development of effective synthetic tools for use in understanding the effect of glycosylation on the structure and function of biomolecules will lead to the development of new strategies to tackle major problems associated with carbohydrate-mediated biological recognitions.
蛋白质糖基化是最复杂的翻译后修饰过程。人类超过50%的蛋白质会发生糖基化，而大肠杆菌等细菌则没有这种修饰机制。许多小分子天然产物也需要糖基化才能发挥其功能。开发有效的合成工具以用于理解糖基化对生物分子结构和功能的影响，将有助于开发新策略来解决与碳水化合物介导的生物识别相关的重大问题。
