Kamp Christel, Christensen Kim
Blackett Laboratory, Imperial College, Prince Consort Road, London SW7 2AZ, United Kingdom.
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Apr;71(4 Pt 1):041911. doi: 10.1103/PhysRevE.71.041911. Epub 2005 Apr 21.
Within a case study on the protein-protein interaction network (PIN) of Drosophila melanogaster we investigate the relation between the network's spectral properties and its structural features. The frequencies of loops of any size within the network can be derived from the spectrum; also the prevalence of specific subgraphs as a result of the network's evolutionary history affects its spectrum. The discrete part of the spectral density shows fingerprints of the PIN's topological features including a preference for loop structures. Duplicate nodes are also characteristic for PINs and we discuss their representation in the PIN's spectrum as well as their biological implications.
在一项关于黑腹果蝇蛋白质-蛋白质相互作用网络（PIN）的案例研究中，我们研究了该网络的光谱特性与其结构特征之间的关系。网络中任何大小的环的频率都可以从光谱中推导出来；此外，作为网络进化历史结果的特定子图的流行程度也会影响其光谱。光谱密度的离散部分显示了PIN拓扑特征的指纹，包括对环结构的偏好。重复节点也是PIN的特征，我们讨论了它们在PIN光谱中的表示及其生物学意义。
