Fridén Barbro, Hreinsson Julius, Hovatta Outi
Department of Obstetrics and Gynaecology, Varberg Hospital, Sweden.
Hum Reprod. 2005 Sep;20(9):2556-8. doi: 10.1093/humrep/dei109. Epub 2005 May 19.
In vitro maturation of oocytes (IVM) has been developed as a treatment option for subjects with good prognosis in assisted reproduction. We present successful IVM treatment in connection with a woman from whom low numbers of embryos were obtained after repeated failed conventional IVF cycles. A 35 year old woman, after 5 years infertility and two intrauterine insemination and three conventional IVF cycles, underwent first an IVM cycle with low dose FSH stimulation, and after failure, another natural IVM cycle. Three oocytes were obtained. After 36 h of IVM the oocytes had reached metaphase II stage, and fertilization using ICSI resulted in one 4-cell stage embryo, which was transferred 2 days later. The result was an uneventful pregnancy and birth of a healthy female infant weighing 4150 g. IVM may be an option for women from whom only low numbers of oocytes are obtained after gonadotrophin stimulation.
卵母细胞体外成熟（IVM）已发展成为辅助生殖中预后良好患者的一种治疗选择。我们报道了一位女性患者成功接受IVM治疗的案例，该患者在多次常规体外受精（IVF）周期失败后仅获得少量胚胎。一名35岁女性，经历了5年不孕、两次宫腔内人工授精和三次常规IVF周期，首先接受了低剂量促卵泡素（FSH）刺激的IVM周期，失败后又进行了一次自然IVM周期。获得了3个卵母细胞。IVM 36小时后，卵母细胞达到减数分裂中期II期，采用卵胞浆内单精子注射（ICSI）受精产生了1个4细胞期胚胎，2天后进行移植。结果是顺利怀孕并产下一名健康女婴，体重4150克。对于在促性腺激素刺激后仅获得少量卵母细胞的女性，IVM可能是一种选择。
