Oliver Javier, Gómez-García María, Paco Laura, López-Nevot Miguel A, Piñero Alexis, Correro Francisco, Martín Leopoldo, Brieva José A, Nieto Antonio, Martín Javier
Instituto de Parasitología y Biomedicina López Neyra, Granada, Spain.
Inflamm Bowel Dis. 2005 Jun;11(6):576-9. doi: 10.1097/01.mib.0000161916.20007.76.
This study investigated the influence of the NFKB1-94ins/delATTG in the susceptibility/phenotype to ulcerative colitis.
We analyzed the distribution of -94ins/delATTG NFKB1 in 258 patients and 264 healthy controls from southern Spain by a polymerase chain reaction-fluorescent method.
The genotype and allele frequencies of -94ins/delATTG did not significantly differ between patients and controls. In fact, the frequency of the -94delATTG allele was almost identical in both groups (34.8% and 35.4%, respectively), and the del/del genotype was underrepresented in UC patients (11.2% versus 14%). In addition, no association of this polymorphism was found with any of the clinical parameters analyzed.
These results suggest that the NFKB1 -94ins/delATTG gene variation, previously associated with UC susceptibility in North Americans, does not influence either susceptibility or phenotype of UC in the Spanish population.
本研究调查了NFKB1 -94ins/delATTG对溃疡性结肠炎易感性/表型的影响。
我们采用聚合酶链反应-荧光法分析了来自西班牙南部的258例患者和264例健康对照中-94ins/delATTG NFKB1的分布情况。
患者和对照之间-94ins/delATTG的基因型和等位基因频率无显著差异。事实上，-94delATTG等位基因在两组中的频率几乎相同（分别为34.8%和35.4%），且UC患者中del/del基因型的比例较低（11.2%对14%）。此外，未发现该多态性与任何分析的临床参数相关。
这些结果表明，先前在北美人群中与UC易感性相关的NFKB1 -94ins/delATTG基因变异，对西班牙人群中UC的易感性或表型均无影响。
