Methylmercury: recent advances in the understanding of its neurotoxicity.
作者信息
Aschner Michael, Syversen Tore
机构信息
Department of Pediatrics and the Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2495, USA.
出版信息
Ther Drug Monit. 2005 Jun;27(3):278-83. doi: 10.1097/01.ftd.0000160275.85450.32.
Abstract
摘要
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本文引用的文献
1
Exploring nonlinear association between prenatal methylmercury exposure from fish consumption and child development: evaluation of the Seychelles Child Development Study nine-year data using semiparametric additive models.探索鱼类消费导致的产前甲基汞暴露与儿童发育之间的非线性关联：使用半参数加法模型对塞舌尔儿童发育研究九年数据的评估。
Environ Res. 2005 Jan;97(1):100-8. doi: 10.1016/j.envres.2004.05.004.
2
The toxicology of mercury--current exposures and clinical manifestations.汞的毒理学——当前暴露情况及临床表现
N Engl J Med. 2003 Oct 30;349(18):1731-7. doi: 10.1056/NEJMra022471.
3
A physicochemical rationale for the biological activity of mercury and its compounds.汞及其化合物生物活性的物理化学原理。
Ann N Y Acad Sci. 1957 Apr 11;65(5):454-60. doi: 10.1111/j.1749-6632.1956.tb36650.x.
4
Using measurement error models to assess effects of prenatal and postnatal methylmercury exposure in the Seychelles Child Development Study.在塞舌尔儿童发展研究中使用测量误差模型评估产前和产后甲基汞暴露的影响。
Environ Res. 2003 Oct;93(2):115-22. doi: 10.1016/s0013-9351(03)00089-6.
5
Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study.在塞舌尔儿童发育研究中，因食用海洋鱼类导致的产前甲基汞暴露情况。
Lancet. 2003 May 17;361(9370):1686-92. doi: 10.1016/S0140-6736(03)13371-5.
6
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Ambul Pediatr. 2003 Jan-Feb;3(1):18-23. doi: 10.1367/1539-4409(2003)003<0018:nrcbsa>2.0.co;2.
7
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8
Investigations of methylmercury-induced alterations in neurogenesis.甲基汞诱导神经发生改变的研究。
Environ Health Perspect. 2002 Oct;110 Suppl 5(Suppl 5):859-64. doi: 10.1289/ehp.02110s5859.
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Brain Pathol. 2002 Oct;12(4):475-81. doi: 10.1111/j.1750-3639.2002.tb00465.x.
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