Duprez D A, Somasundaram P E, Sigurdsson G, Hoke L, Florea N, Cohn J N
Department of Medicine, Rasmussen Center for Cardiovascular Disease Prevention, Cardiovascular Division, University of Minnesota Medical School, Minneapolis, 55455, USA.
J Hum Hypertens. 2005 Jul;19(7):515-9. doi: 10.1038/sj.jhh.1001860.
Plasma concentration of high sensitive C-reactive protein (hsCRP) is used as a marker for inflammatory states and is directly correlated with the risk for coronary heart disease. Evidence concerning the role of inflammation in atheroma formation has been derived from several models of atherosclerosis. Inflammation should exert its adverse vascular effects by structural changes in the artery wall and consequently alterations in arterial elasticity, which could be detected already in asymptomatic early vascular disease. We hypothesized that CRP is related to large artery elasticity, but not to small artery elasticity in early vascular disease. Therefore, we examined the association between arterial stiffness of large and small arteries and inflammation in an asymptomatic population referred for primary prevention cardiovascular screening. Studies were performed in 391 subjects (age 21-82 years; 254 men, 137 women) who underwent screening at the Cardiovascular Disease Prevention Center. Large artery (C1) and small artery (C2) elasticity indices were obtained by the CVProfiler 2000 (HDI, Eagan, MN, USA). After overnight fasting, venous samples were taken for measurement of hsCRP, lipids, glucose. There was a significant inverse correlation between hsCRP (0.29 +/- 0.40 mg/dl) and C1 (16.7 +/- 5.8 ml/mmHg), r = -0.133, P = 0.01; there was no significant correlation between hsCRP and C2 (6.6 +/- 3.2 ml/mmHg). C2, but not hsCRP, was inversely correlated with age, abnormal lipids and glucose, whereas C1, but not hsCRP, was inversely correlated with age and systolic blood pressure (SBP). In multiple regression analysis, the relationship between hsCRP and C1 was not affected by age, body mass index, SBP, serum glucose or lipids. In conclusion, these findings support the hypothesis that hsCRP, a marker for acute and low-grade inflammation, is associated with large artery but not with small artery elasticity in asymptomatic individuals undergoing primary prevention cardiovascular screening.
高敏C反应蛋白（hsCRP）的血浆浓度被用作炎症状态的标志物，并且与冠心病风险直接相关。关于炎症在动脉粥样硬化形成中作用的证据来自多种动脉粥样硬化模型。炎症应通过动脉壁的结构变化进而导致动脉弹性改变来发挥其不良血管效应，而这种改变在无症状的早期血管疾病中就已能被检测到。我们假设在早期血管疾病中，CRP与大动脉弹性相关，但与小动脉弹性无关。因此，我们在一组因心血管疾病一级预防筛查而转诊的无症状人群中，研究了大动脉和小动脉的动脉僵硬度与炎症之间的关联。对391名受试者（年龄21 - 82岁；男性254名，女性137名）进行了研究，这些受试者在心血管疾病预防中心接受了筛查。通过CVProfiler 2000（美国明尼苏达州伊根市HDI公司）获得大动脉（C1）和小动脉（C2）弹性指数。过夜禁食后，采集静脉血样用于检测hsCRP、血脂和血糖。hsCRP（0.29±0.40mg/dl）与C1（16.7±5.8ml/mmHg）之间存在显著负相关，r = -0.133，P = 0.01；hsCRP与C2（6.6±3.2ml/mmHg）之间无显著相关性。C2与年龄、血脂异常和血糖呈负相关，而hsCRP与这些因素无关；C1与年龄和收缩压（SBP）呈负相关，而hsCRP与这些因素无关。在多元回归分析中，hsCRP与C1之间的关系不受年龄、体重指数、SBP、血糖或血脂的影响。总之，这些发现支持了这样的假设，即hsCRP作为急性和低度炎症的标志物，在接受心血管疾病一级预防筛查的无症状个体中，与大动脉弹性相关，但与小动脉弹性无关。
