Oliveira A L, Mano J F, Román J San, Reis R L
3B's Research Group - Biomaterials, Biodegradables & Biomimetics, University of Minho, Campus de Gualtar, Braga, Portugal.
J Biomed Mater Res B Appl Biomater. 2005 Jul;74(1):560-9. doi: 10.1002/jbm.b.30260.
In this work, the effects of beta-radiation are assessed, for the first time, on starch-based biodegradable polymers, with the aim of using it as an alternative sterilization process to the previously studied sterilization methods. Different doses of radiation were used in order to investigate the possibility of using this sterilization technique as a treatment to tailor the surface and bulk properties (namely mechanical) of these polymers. The as-treated substrates were characterized by water-uptake measurements and contact angle (theta) measurements. The mechanical properties of the materials were characterized by tensile tests by means of ultimate tensile strength (UTS) and strain at break (epsilon). The fracture of the surfaces was observed by scanning electron microscopy (SEM). Dynamic mechanical analysis (DMA) was also used to characterize the viscolelastic behavior of the irradiated materials. The main effect of sterilization with beta-radiation over the starch-based polymers seems to be a surface modification by an increase of the hydrophilicity. Nevertheless, because beta-radiation did not significantly affect the mechanical properties, it can be regarded as an effective way of modifying the surface for applications were more hydrophilic surfaces are desirable.
在这项工作中，首次评估了β辐射对淀粉基可生物降解聚合物的影响，目的是将其用作先前研究的灭菌方法的替代灭菌工艺。使用了不同剂量的辐射，以研究将这种灭菌技术用作调整这些聚合物的表面和本体性能（即机械性能）的处理方法的可能性。通过吸水率测量和接触角（θ）测量对处理后的基材进行表征。通过拉伸试验，借助极限拉伸强度（UTS）和断裂应变（ε）对材料的机械性能进行表征。通过扫描电子显微镜（SEM）观察表面的断裂情况。还使用动态力学分析（DMA）来表征辐照材料的粘弹性行为。β辐射灭菌对淀粉基聚合物的主要影响似乎是通过增加亲水性进行表面改性。然而，由于β辐射对机械性能没有显著影响，因此对于需要更亲水表面的应用而言，它可被视为一种有效的表面改性方法。
