3B's Research Group-Biomaterials, Biodegradables and Biomimetics, University of Minho, AvePark, Taipas, Guimarães, Portugal.
J Mater Sci Mater Med. 2010 Jan;21(1):21-32. doi: 10.1007/s10856-009-3831-0. Epub 2009 Jul 29.
Radiation is widely used in biomaterials science for surface modification and sterilization. Herein, we describe the use of plasma and UV-irradiation to improve the biocompatibility of different starch-based blends in terms of cell adhesion and proliferation. Physical and chemical changes, introduced by the used methods, were evaluated by complementary techniques for surface analysis such as scanning electron microscopy, atomic force microscopy, contact angle analysis and X-ray photoelectron spectroscopy. The effect of the changed surface properties on the adhesion of osteoblast-like cells was studied by a direct contact assay. Generally, both treatments resulted in higher number of cells adhered to the modified surfaces. The importance of the improved biocompatibility resulting from the irradiation methods is further supported by the knowledge that both UV and plasma treatments can be used as cost-effective methods for sterilization of biomedical materials and devices.
辐射在生物材料科学中被广泛用于表面改性和灭菌。在此，我们描述了使用等离子体和紫外辐射来提高不同淀粉基共混物的细胞黏附和增殖方面的生物相容性。通过扫描电子显微镜、原子力显微镜、接触角分析和 X 射线光电子能谱等表面分析互补技术，评估了所采用方法带来的物理和化学变化。通过直接接触测定法研究了表面性能变化对成骨样细胞黏附的影响。通常，两种处理方法都导致更多的细胞黏附在改性表面上。由于辐照方法导致的生物相容性提高的重要性，进一步得到了支持，即知道 UV 和等离子体处理都可以作为生物医学材料和器械的成本效益高的灭菌方法。
