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[TIC4]endomorphins, analogues of endomorphins, have significantly enhanced vasorelaxant effects in rat aorta rings.

作者信息

Zhao Qian-Yu, Chen Qiang, Feng Yun, Lin Xin, Wang Rui

机构信息

Department of Biochemistry and Molecular Biology, School of Life Science, Lanzhou University, Peoples Republic of China.

出版信息

Protein Pept Lett. 2005 May;12(4):323-6. doi: 10.2174/0929866053765743.

DOI:10.2174/0929866053765743
PMID:15907175
Abstract

[Tic(4)]EM1 and [Tic(4)]EM2, new endomorphins (EMs) analogues, caused relaxation of rat aorta rings precontracted with phenylphrine in a concentration-dependent manner and were 240- to 370-fold more potent than EMs. This effect was inhibited by endothelium removal or by incubation with NO synthase inhibitor L-NNA or opioid receptor antagonist naloxone. The results demonstrate that [Tic(4)]EMs have NO- and endothelium-dependent vasorelaxant effects which are mediated by the opioid receptor.

摘要

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