Baulon Emmanuelle, Fraser William D, Piedboeuf Bruno, Buekens Pierre, Xiong Xu
Department of Obstetrics and Gynecology, CHU Strasbourg, France.
BMC Pregnancy Childbirth. 2005 May 20;5:10. doi: 10.1186/1471-2393-5-10.
No previous studies have examined the effect of pregnancy-induced hypertension (PIH) on early infant growth. The objective was to study infant growth patterns of babies born to mothers with PIH at 28 and 42 days postpartum.
We conducted a population-based retrospective cohort study of 16,936 pregnancies delivered between January 1, 1989 through December 31, 1990 in Suzhou, China. PIH was classified as gestational hypertension, preeclampsia and severe preeclampsia. Infant Growth Percentage (IGP) was calculated as the weight gain from birth to infant weight at 28 or 42 days postpartum divided by the birth weight. Univariate analysis and multivariate linear regression were performed to compare the infant weight as well as IGP at 28 and 42 days postpartum between various types of PIH and the normotensive group.
Infant weights at 28 and 42 days postpartum were significantly lower in severe preeclampsia (e.g., 4679.9 g at 42 days) and preeclampsia (e.g., 4763.8 g at 42 days) groups than in the normotensive group (e.g., 4869.1 g at 42 days, p < 0.01). However, there were no differences in IGP between groups. After stratifying by intrauterine growth restriction (IUGR) status, if babies were not intrauterine growth restricted, none of the PIH types showed a significantly lower weight at 28 and 42 days postpartum and their IGPs were similar to those of the reference group. When babies were growth restricted, all PIH groups showed significantly lower weights but higher IGP at 28 and 42 days postpartum as compared to the normotensive group.
Infants born to mothers with PIH but without IUGR have normal early infant growth. IUGR secondary to PIH is associated with significant catch-up growth at 28 and 42 days postpartum.
既往尚无研究探讨妊娠高血压综合征（PIH）对婴儿早期生长的影响。目的是研究产后28天和42天患有PIH的母亲所生婴儿的生长模式。
我们对1989年1月1日至1990年12月31日在中国苏州分娩的16936例妊娠进行了一项基于人群的回顾性队列研究。PIH分为妊娠期高血压、子痫前期和重度子痫前期。婴儿生长百分比（IGP）计算为产后28天或42天婴儿体重相对于出生体重的增加量除以出生体重。采用单因素分析和多因素线性回归比较不同类型PIH组与血压正常组产后28天和42天的婴儿体重及IGP。
重度子痫前期组（如产后42天为4679.9克）和子痫前期组（如产后42天为4763.8克）产后28天和42天的婴儿体重显著低于血压正常组（如产后42天为4869.1克，p<0.01）。然而，各组间IGP无差异。按宫内生长受限（IUGR）状态分层后，如果婴儿无宫内生长受限，产后28天和42天PIH各类型的体重均无显著降低，其IGP与参照组相似。当婴儿生长受限时，与血压正常组相比，所有PIH组产后28天和42天的体重均显著降低，但IGP较高。
PIH母亲所生但无IUGR的婴儿早期生长正常。PIH继发的IUGR与产后28天和42天显著的追赶生长有关。
