Xiong Xu, Buekens Pierre, Pridjian Gabriella, Fraser William D
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, Tidewater Building, Suite 2022, SL-18, 1440 Canal Street, New Orleans, LA 70112, USA.
J Reprod Med. 2007 May;52(5):402-6.
To examine the association between pregnancy-induced hypertension (PIH) and perinatal mortality.
A population-based, retrospective, cohort study was conducted based on 16,936 pregnancies delivered between January 1, 1989, and December 31, an infant 1990, in Suzhou, China. PIH growth was classified as gestational hypertension, preeclampsia or severe preeclampsia.
The perinatal mortality was 10.2 per thousand in normotensive women, 10.3 per thousand in women with gestational hypertension, 17.8 per thousand in women with preeclampsia and 37.0 per thousand in women with severe preeclampsia. Severe preeclampsia was associated with 3.4-fold increased perinatal mortality. After stratifying by intrauterine growth restriction status, if infants were not intrauterine growth restricted, all types of PIH were not associated with increased perinatal mortality. However, when infants were intrauterine growth restricted, all types of PIH were associated with markedly increased perinatal mortality (e.g., 15-fold increased mortality for severe preeclampsia).
Intrauterine growth restriction secondary to PIH is associated with significantly increased perinatal mortality.
探讨妊娠高血压综合征（PIH）与围产期死亡率之间的关联。
基于1989年1月1日至1990年12月31日在中国苏州分娩的16936例妊娠进行了一项基于人群的回顾性队列研究。PIH的病情分为妊娠期高血压、先兆子痫或重度先兆子痫。
血压正常的女性围产期死亡率为千分之10.2，妊娠期高血压女性为千分之10.3，先兆子痫女性为千分之17.8，重度先兆子痫女性为千分之37.0。重度先兆子痫与围产期死亡率增加3.4倍相关。按胎儿生长受限状态分层后，如果婴儿无胎儿生长受限，所有类型的PIH均与围产期死亡率增加无关。然而，当婴儿存在胎儿生长受限时，所有类型的PIH均与围产期死亡率显著增加相关（例如，重度先兆子痫死亡率增加15倍）。
PIH继发的胎儿生长受限与围产期死亡率显著增加相关。
