澳大利亚儿童乳糜泻的年龄相关临床特征。
Age related clinical features of childhood coeliac disease in Australia.
作者信息
Stone Monique L, Bohane Timothy D, Whitten Kylie E, Tobias Vivienne H, Day Andrew S
机构信息
Department of General Paediatrics, Sydney Children's Hospital, High St Randwick, NSW 2031, Australia.
出版信息
BMC Pediatr. 2005 May 21;5(1):11. doi: 10.1186/1471-2431-5-11.
BACKGROUND
To describe the presenting clinical features of coeliac disease in a single paediatric centre, and to determine if the presenting features vary with age.
METHODS
A review was conducted of children who had been referred with clinical suspicion of coeliac disease to the paediatric gastroenterology department of a tertiary paediatric hospital in Sydney, Australia. Coeliac disease was defined using standard histological criteria. Medical records were reviewed retrospectively.
RESULTS
Clinical data were available for 74 cases of proven coeliac disease. Only 9% of patients were less than 2 years of age at diagnosis. Pre-school children (age < 5 years) presented with different symptoms to school children (age > or = 5 years). The most common presenting features in younger children were diarrhoea, irritability and weight loss. However, in older children, abdominal pain was the most common presenting feature.
CONCLUSION
We found a significant difference in the clinical features of coeliac disease in pre-school compared to school age children.
背景
描述澳大利亚悉尼一家三级儿科医院儿科胃肠病科因临床怀疑乳糜泻而转诊儿童的临床表现，并确定这些表现是否随年龄而变化。
方法
对转诊至澳大利亚悉尼一家三级儿科医院儿科胃肠病科且临床怀疑乳糜泻的儿童进行回顾性研究。乳糜泻采用标准组织学标准进行定义。对病历进行回顾性分析。
结果
有74例确诊乳糜泻患者的临床资料。仅9%的患者诊断时年龄小于2岁。学龄前儿童（年龄<5岁）与学龄儿童（年龄≥5岁）的症状表现不同。年幼儿童最常见的表现为腹泻、易激惹和体重减轻。然而，年龄较大儿童中，腹痛是最常见的表现。
结论
我们发现学龄前儿童与学龄儿童乳糜泻的临床特征存在显著差异。
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