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蹒跚基因缩短了雌性的生殖寿命。

The staggerer gene curtails the reproductive life span of females.

作者信息

Guastavino J M, Larsson K

机构信息

Laboratoire d'Ethologie et Sociobiologie, URA CNRS No 667, Université Paris XIII, Villetaneuse, France.

出版信息

Behav Genet. 1992 Jan;22(1):101-12. doi: 10.1007/BF01066795.

DOI:10.1007/BF01066795
PMID:1590727
Abstract

Three studies were undertaken to investigate some features of the reproductive activity of female staggerer mice of the C57BL/6 strain. It was found that in the staggerer female, (1) vaginal opening and onset of vaginal estrous cycling were delayed; (2) the vaginal estrous cycle was irregular and characterized by abnormally prolonged diestrous and estrous phases, and (3) the reproductive life span of the mutant female was confined to a 3-month period after puberty. The abnormalities observed in sexual functions suggest a specific influence of the staggerer gene on reproductive activity.

摘要

开展了三项研究以调查C57BL/6品系雌性蹒跚小鼠生殖活动的一些特征。结果发现,在蹒跚雌性小鼠中,(1)阴道开口和阴道发情周期的开始延迟;(2)阴道发情周期不规则,其特征为动情间期和发情期异常延长,并且(3)突变雌性小鼠的生殖寿命局限于青春期后的3个月期间。在性功能方面观察到的异常表明蹒跚基因对生殖活动有特定影响。

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1
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本文引用的文献

1
The swimming activity of the staggerer mutant mouse.蹒跚突变小鼠的游泳活动。
Behav Processes. 1986 Sep;13(3):287-99. doi: 10.1016/0376-6357(86)90091-4.
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Responses to novelty in staggerer mutant mice.蹒跚突变小鼠对新奇事物的反应。
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与年龄相关的浦肯野细胞死亡依赖于类固醇:RORα单倍体不足会损害血浆和小脑类固醇以及浦肯野细胞的存活。
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In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism.孤儿核受体RORα在骨代谢中作用的体外和体内证据
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Maintenance by L-DOPA treatment of estrous cycles and LH response to estrogen in aging female rats.
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Nest-building behavior in two cerebellar mutant mice: staggerer and weaver.
Behav Neural Biol. 1982 Sep;36(1):94-7. doi: 10.1016/s0163-1047(82)90289-8.
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Constraint of the mother with pups restores some aspects of the maternal behavior of mutant staggerer mice.
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10
Multiple innervation of Purkinje cells by climbing fibers in the cerebellum of the adult staggerer mutant mouse.成年蹒跚突变小鼠小脑浦肯野细胞受攀缘纤维的多重支配
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