Deiss V, Baudoin C
Laboratoire d'Ethologie Expérimentale et Comparée, URA CNRS 667, Université Paris XIII, Villetaneuse, France.
Physiol Behav. 1997 Feb;61(2):209-13. doi: 10.1016/s0031-9384(96)00402-7.
To address the hypothesis that reproductive deficits in male house mice expressing the staggerer mutation are due to chemosensory deficits, we examined behavioral responses to odorants. Two-choice tests (butanol or vanillin vs. amyl acetate odors) were used to determine behavioral thresholds for butanol, an aversive odor, and for vanillin, an attractive odor. Two groups of C57B1/6 male mice (one nonmutant group and one mutant group) were studied using an olfactometer. Different concentrations of butanol were used: from 5.5 x 10(-4) M to 5.5 x 10(-1) M. Vanillin at different concentrations, from 6.6 x 10(-5) M to 6.6 x 10(-2) M, was presented during the tests after a 1-month period of familiarization. Aversive and attractive behavioral thresholds of staggerer mice were higher than those of nonmutant mice. The staggerer mutation induces hyposmia in mice. This olfactory deficit could explain, at least partially, abnormalities in the social and sexual behaviors of staggerer mice.
为了验证表达蹒跚突变的雄性家鼠生殖缺陷是由化学感觉缺陷所致这一假设，我们检测了其对气味剂的行为反应。采用二选一测试（丁醇或香草醛与乙酸戊酯气味对比）来确定对厌恶气味丁醇和诱人气味香草醛的行为阈值。使用嗅觉计对两组C57B1/6雄性小鼠（一组非突变组和一组突变组）进行研究。使用了不同浓度的丁醇：从5.5×10⁻⁴ M到5.5×10⁻¹ M。在经过1个月的适应期后，测试期间呈现不同浓度的香草醛，范围从6.6×10⁻⁵ M到6.6×10⁻² M。蹒跚小鼠的厌恶和诱人行为阈值高于非突变小鼠。蹒跚突变会导致小鼠嗅觉减退。这种嗅觉缺陷至少可以部分解释蹒跚小鼠在社交和性行为方面的异常。
