Ro在RNA识别中的作用。
Ro's role in RNA reconnaissance.
作者信息
MacRae Ian J, Doudna Jennifer A
机构信息
Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720.
Howard Hughes Medical Institute, Department of Molecular & Cell Biology and Department of Chemistry, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720; Physical Biosciences Division, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California 94720.
出版信息
Cell. 2005 May 20;121(4):495-496. doi: 10.1016/j.cell.2005.05.004.
The Ro 60 kDa autoantigen binds misfolded RNAs and likely functions in small RNA quality control. In this issue of Cell, Stein et al. (2005) present crystal structures of Ro alone and bound to both double- and single-stranded RNA, revealing two distinct RNA binding sites that suggest how Ro may distinguish between native and misfolded small RNAs.
Ro 60 kDa自身抗原可结合错误折叠的RNA，可能在小RNA质量控制中发挥作用。在本期《细胞》杂志中，斯坦因等人（2005年）展示了单独的Ro以及与双链和单链RNA结合的Ro的晶体结构，揭示了两个不同的RNA结合位点，这表明Ro可能如何区分天然和错误折叠的小RNA。
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