Chen X, Quinn A M, Wolin S L
Department of Cell Biology and Molecular Biophysics, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA.
Genes Dev. 2000 Apr 1;14(7):777-82.
The genome of the radiation-resistant eubacterium Deinococcus radiodurans contains an ortholog of an RNA-binding protein known as the Ro 60-kD autoantigen. This protein, which was previously identified only in higher eukaryotes, is normally bound to small RNAs known as Y RNAs. We show that the Ro protein ortholog Rsr contributes to the resistance of D. radiodurans to UV irradiation. Rsr binds several small RNAs, encoded upstream of rsr, that accumulate following UV irradiation. One of these RNAs resembles a Y RNA. These results suggest that Ro RNPs could similarly contribute to the recovery of higher cells following UV irradiation.
抗辐射真细菌耐辐射球菌的基因组中含有一种RNA结合蛋白的直系同源物,该蛋白被称为Ro 60-kD自身抗原。这种蛋白以前仅在高等真核生物中被鉴定出来,通常与被称为Y RNA的小RNA结合。我们发现,Ro蛋白直系同源物Rsr有助于耐辐射球菌抵抗紫外线照射。Rsr与rsr上游编码的几种小RNA结合,这些小RNA在紫外线照射后会积累。其中一种RNA类似于Y RNA。这些结果表明,Ro核糖核蛋白(RNP)可能同样有助于高等细胞在紫外线照射后的恢复。