Tapsoba I, Belgaied J-E, Boujlel K
Laboratoire de Chimie Analytique et d'Electrochimie, Faculté des Sciences de Tunis, Département de Chimie, Campus Universitaire, 2029 El Manar, Tunis, Tunisia.
J Pharm Biomed Anal. 2005 Jun 1;38(1):162-5. doi: 10.1016/j.jpba.2004.11.056. Epub 2005 Jan 11.
The electrochemical oxidation of Guaifenesin in a pharmaceutical formulation containing Guaifenesin has been carried out in Britton-Robinson buffer (BRB) (0.04 mol L-1) on platinum electrode. Guaifenesin exhibits a well-defined irreversible oxidation peak at 0.924 V/ref. The influence of pH on the oxidation of Guaifenesin was studied in BRB (pH range 2-5). A method for the analysis of Guaifenesin in BRB (0.04 mol L-1, pH 2), which allows quantification over the range 20-60 microg mL-1, was proposed and successfully applied to the determination of Guaifenesin in syrup with mean recovery and relative standard deviation of 103.3% and 1.32%, respectively.
