Harvey Elizabeth J, Ramji Dipak P
Cardiff School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK.
Cardiovasc Res. 2005 Jul 1;67(1):11-20. doi: 10.1016/j.cardiores.2005.04.019.
Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling.
动脉粥样硬化被认为是一种由细胞间和细胞内信号通路复杂网络调控的慢性炎症形式。多效细胞因子干扰素-γ（IFN-γ）是一种关键的促炎介质，在动脉粥样硬化病变中高水平表达。IFN-γ调节血管壁中所有细胞类型的功能和特性。IFN-γ在动脉粥样硬化发生中的精确作用很复杂，已发现其具有促动脉粥样硬化和抗动脉粥样硬化的作用。本综述将讨论该细胞因子的这些作用，以及从缺乏IFN-γ信号的动脉粥样硬化小鼠模型中获得的最新研究结果。
