Kimura Kenta, Isowa Tokiko, Ohira Hideki, Murashima Seikou
Nagoya University Graduate School of Environmental Studies, Nagoya 464-8601, Japan.
Biol Psychol. 2005 Oct;70(2):131-9. doi: 10.1016/j.biopsycho.2004.12.006.
Sympathetic nervous activity plays a prominent role in acute stress responses in the immune system, enhancement of innate immunity and suppression of specific immunity. The present study was conducted to examine the temporal characteristics of such immune responses to acute stress and to determine their association with sympathetic activity in detail. For this purpose, 15 female undergraduates engaged in a continuous mental arithmetic task for 14 min, and we collected their blood samples for immune indices (CD3+ T cells, CD4+ T cells, NK cells) each 3 min during the task and saliva samples before and after the task. Our results showed that the proportion of Natural Killer cells (NK cells) increased even 2 min after initiation of the task, whereas proportions of CD3+ and CD4+ lymphocytes decreased 8 min after initiation of the task. Moreover, we found significant correlations between cardiovascular activity and the variations of immune indices.
交感神经活动在免疫系统的急性应激反应、先天免疫增强和特异性免疫抑制中起着重要作用。本研究旨在检查此类急性应激免疫反应的时间特征，并详细确定它们与交感神经活动的关联。为此，15名女大学生进行了14分钟的连续心算任务，我们在任务期间每隔3分钟采集她们的血液样本以检测免疫指标（CD3+T细胞、CD4+T细胞、自然杀伤细胞），并在任务前后采集唾液样本。我们的结果表明，任务开始后2分钟自然杀伤细胞（NK细胞）的比例就有所增加，而任务开始后8分钟CD3+和CD4+淋巴细胞的比例下降。此外，我们发现心血管活动与免疫指标变化之间存在显著相关性。
