Huang Chun-Jung, Zourdos Michael C, Jo Edward, Ormsbee Michael J
Department of Exercise Science and Health Promotion, Florida Atlantic University, 777 Glades Road, FH11A-126B, Boca Raton, FL 33431, USA.
ScientificWorldJournal. 2013 Nov 7;2013:752071. doi: 10.1155/2013/752071.
Research examining immune function during obesity suggests that excessive adiposity is linked to impaired immune responses leading to pathology. The deleterious effects of obesity on immunity have been associated with the systemic proinflammatory profile generated by the secretory molecules derived from adipose cells. These include inflammatory peptides, such as TNF- α , CRP, and IL-6. Consequently, obesity is now characterized as a state of chronic low-grade systemic inflammation, a condition considerably linked to the development of comorbidity. Given the critical role of adipose tissue in the inflammatory process, especially in obese individuals, it becomes an important clinical objective to identify lifestyle factors that may affect the obesity-immune system relationship. For instance, stress, physical activity, and nutrition have each shown to be a significant lifestyle factor influencing the inflammatory profile associated with the state of obesity. Therefore, the purpose of this review is to comprehensively evaluate the impact of lifestyle factors, in particular psychological stress, physical activity, and nutrition, on obesity-related immune function with specific focus on inflammation.
对肥胖期间免疫功能的研究表明，过多的肥胖与导致病理状态的免疫反应受损有关。肥胖对免疫的有害影响与脂肪细胞分泌分子产生的全身性促炎状态有关。这些分子包括炎性肽，如肿瘤坏死因子-α、C反应蛋白和白细胞介素-6。因此，肥胖现在被描述为一种慢性低度全身性炎症状态，这种状态与合并症的发生密切相关。鉴于脂肪组织在炎症过程中的关键作用，尤其是在肥胖个体中，识别可能影响肥胖与免疫系统关系的生活方式因素成为一项重要的临床目标。例如，压力、体育活动和营养都已被证明是影响与肥胖状态相关的炎症状态的重要生活方式因素。因此，本综述的目的是全面评估生活方式因素，特别是心理压力、体育活动和营养，对肥胖相关免疫功能的影响，特别关注炎症。
