利用基本的化学增敏药效团假说。第1部分：新型芳基溴化物和双环化学增敏剂对耐药疟原虫的合成及生物学评价。
Exploiting a basic chemosensitizing pharmacophore hypothesis. Part 1: synthesis and biological evaluation of novel arylbromide and bicyclic chemosensitizers against drug-resistant malaria parasites.
作者信息
Chouteau Franck, Ramanitrahasimbola David, Rasoanaivo Philippe, Chibale Kelly
机构信息
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
出版信息
Bioorg Med Chem Lett. 2005 Jun 15;15(12):3024-8. doi: 10.1016/j.bmcl.2005.04.033.
PMID:15908208
Abstract
An exploratory series of novel arylbromide and bicyclic chemosensitizers (modulators) against chloroquine-resistant Plasmodium falciparum were designed and synthesized on the basis of a basic chemosensitizing pharmacophore hypothesis in malaria. ortho-Substituted bromo and biphenyl ether compounds displayed the best activity from the series.
摘要
基于疟疾中一种基本的化学增敏药效团假说，设计并合成了一系列针对氯喹抗性恶性疟原虫的新型芳基溴化物和双环化学增敏剂（调节剂）。邻位取代的溴化物和联苯醚化合物在该系列中表现出最佳活性。
Zotero 插件