Ting Pauline C, Umland Shelby P, Aslanian Robert, Cao Jianhua, Garlisi Charles G, Huang Ying, Jakway James, Liu Zhidan, Shah Himanshu, Tian Fang, Wan Yuntao, Shih Neng-Yang
Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Bioorg Med Chem Lett. 2005 Jun 15;15(12):3020-3. doi: 10.1016/j.bmcl.2005.04.054.
Structure-activity relationship study of bipiperidine amide 1 has identified the reverse bipiperidine amide 4a as a CC chemokine-3 (CCR3) receptor antagonist. Optimization of the structure-activity relationship of compound 4a has resulted in the identification of a CCR3 antagonist 4i as well as a CCR3 agonist 13.
双哌啶酰胺1的构效关系研究已确定反向双哌啶酰胺4a为CC趋化因子3（CCR3）受体拮抗剂。对化合物4a构效关系的优化已导致确定了一种CCR3拮抗剂4i以及一种CCR3激动剂13。
