Ouguerram K, Magot T, Lutton C
Laboratoire de Physiologie de la Nutrition, Orsay, France.
Atherosclerosis. 1992 Apr;93(3):201-8. doi: 10.1016/0021-9150(92)90256-g.
Experiments were carried out to compare the catabolism of intestinal lipoproteins between genetically hypercholesterolemic (RICO) and normocholesterolemic (SW) rats. Kinetics of plasma cholesteryl ester were studied after injection of cholesterol-labeled chylomicrons or VLDL. The chylomicron clearance is reduced in the RICO rat (rate constant, K = 7.2 +/- 0.1 h-1 vs. 10.7 +/- 0.1 h-1 in SW rat), while a much more minor alteration was observed in the catabolism of lymph VLDL (K = 4.3 +/- 0.6 h-1 in the RICO rat vs. 5.1 +/- 0.4 h-1). The injection of chylomicrons from SW rats to RICO rats and from RICO rats to SW rats showed that the fall in the rate of catabolism of chylomicrons in RICO rats was not secondary to an increase in the production rate, but was related to the lipoprotein particle itself without any alteration of the catabolic system. The reduction in the rate of catabolism of chylomicrons in the RICO rat could be related to a change in their apolipoprotein composition (increase in the proportion of apolipoprotein E = 12 +/- 2% vs. 3 +/- 1% in the SW rat).
开展实验以比较遗传性高胆固醇血症（RICO）大鼠和正常胆固醇血症（SW）大鼠肠道脂蛋白的分解代谢情况。注射胆固醇标记的乳糜微粒或极低密度脂蛋白（VLDL）后，研究血浆胆固醇酯的动力学。RICO大鼠的乳糜微粒清除率降低（速率常数，K = 7.2±0.1 h⁻¹，而SW大鼠为10.7±0.1 h⁻¹），而在淋巴VLDL的分解代谢中观察到的变化则小得多（RICO大鼠中K = 4.3±0.6 h⁻¹，SW大鼠中为5.1±0.4 h⁻¹）。将SW大鼠的乳糜微粒注射到RICO大鼠以及将RICO大鼠的乳糜微粒注射到SW大鼠的实验表明，RICO大鼠中乳糜微粒分解代谢速率的下降并非继发于生成速率的增加，而是与脂蛋白颗粒本身有关，且分解代谢系统未发生任何改变。RICO大鼠中乳糜微粒分解代谢速率的降低可能与其载脂蛋白组成的变化有关（载脂蛋白E的比例增加，SW大鼠中为3±1%，RICO大鼠中为12±2%）。
