Baghestani Shahram, Khosravi Farrokh, Dehghani Zahedani Mohsen, Mahboobi Abdol-Ali
Hormozgan University of Medical Sciences, Bandar Abbas Medical School, Department of Dermatology, PO Box 79145-3654, Bandar Abbas, Iran.
Eur J Dermatol. 2005 May-Jun;15(3):196-200.
Multicentric reticulohistiocytosis is a rare multisystem disease, presenting with skin lesions and erosive polyarthritis, which is often associated with malignancy. A 2 year untreated natural course of multicentric reticulohistiocytosis, in which the typical nodular skin manifestation of the disease and polyarticular arthritis was present, is described in a 34-year-old lady with no history of major medical disease. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm. Massive destruction of articular surfaces and new papular skin lesions accompanied by atrophic scars of previous skin lesions developed after 2 years of untreated active disease.
多中心性网状组织细胞增生症是一种罕见的多系统疾病，表现为皮肤损害和侵蚀性多关节炎，常与恶性肿瘤相关。本文描述了一名34岁无重大病史的女性患者，其多中心性网状组织细胞增生症未经治疗的自然病程长达2年，期间出现了该疾病典型的结节性皮肤表现和多关节关节炎。组织病理学显示特征性的组织细胞和多核巨细胞浸润，细胞质呈磨砂玻璃样。未经治疗的活动性疾病持续2年后，关节面出现大量破坏，新的丘疹性皮肤损害出现，同时伴有既往皮肤损害的萎缩性瘢痕。
