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2

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本文引用的文献

1

Selected topics from classical bacterial genetics.经典细菌遗传学选讲

Curr Protoc Mol Biol. 2002 Aug;Chapter 1:Unit 1.4. doi: 10.1002/0471142727.mb0104s59.

2

Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence.参与无氧呼吸的酶似乎在胸膜肺炎放线杆菌的毒力中发挥作用。

Infect Immun. 2005 Jan;73(1):226-34. doi: 10.1128/IAI.73.1.226-234.2005.

3

Cloning and characterization of the Actinobacillus pleuropneumoniae fur gene and its role in regulation of ApxI and AfuABC expression.

DNA Seq. 2003 Jun;14(3):169-81. doi: 10.1080/1042517031000089469.

4

Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.鉴定胸膜肺炎放线杆菌在其自然宿主感染期间生存所必需的基因。

Infect Immun. 2003 Jul;71(7):3960-70. doi: 10.1128/IAI.71.7.3960-3970.2003.

5

NapA protects Helicobacter pylori from oxidative stress damage, and its production is influenced by the ferric uptake regulator.NapA可保护幽门螺杆菌免受氧化应激损伤，其产生受铁摄取调节因子的影响。

J Med Microbiol. 2003 Jun;52(Pt 6):461-469. doi: 10.1099/jmm.0.05070-0.

6

Inactivation of the Moraxella catarrhalis 7169 ferric uptake regulator increases susceptibility to the bactericidal activity of normal human sera.卡他莫拉菌7169铁摄取调节因子的失活增加了对正常人血清杀菌活性的敏感性。

Infect Immun. 2003 Apr;71(4):1843-8. doi: 10.1128/IAI.71.4.1843-1848.2003.

7

Resistance to hydrogen peroxide in Helicobacter pylori: role of catalase (KatA) and Fur, and functional analysis of a novel gene product designated 'KatA-associated protein', KapA (HP0874).幽门螺杆菌对过氧化氢的抗性：过氧化氢酶（KatA）和铁摄取调节蛋白（Fur）的作用，以及一种名为“KatA相关蛋白”（KapA，HP0874）的新型基因产物的功能分析。

Microbiology (Reading). 2002 Dec;148(Pt 12):3813-3825. doi: 10.1099/00221287-148-12-3813.

8

Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection.两种转铁蛋白结合蛋白都是胸膜肺炎放线杆菌7型感染中的毒力因子。

FEMS Microbiol Lett. 2002 Apr 9;209(2):283-7. doi: 10.1111/j.1574-6968.2002.tb11145.x.

9

In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and Is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis.在金黄色葡萄球菌中，铁摄取调节蛋白（Fur）是一种与PerR相互作用的调节因子，有助于毒力，并且通过对过氧化氢酶的正向调节和铁稳态对氧化应激抗性是必需的。

J Bacteriol. 2001 Jan;183(2):468-75. doi: 10.1128/JB.183.2.468-475.2001.

10

Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response.胸膜肺炎放线杆菌的铁转运与脲酶活性：对细菌毒力和宿主免疫反应的影响

Infect Immun. 2001 Jan;69(1):472-8. doi: 10.1128/IAI.69.1.472-478.2001.

铁摄取调节蛋白Fur的缺失会损害胸膜肺炎放线杆菌的体外生长和毒力。

Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.

作者信息

Jacobsen Ilse, Gerstenberger Jörg, Gruber Achim D, Bossé Janine T, Langford Paul R, Hennig-Pauka Isabel, Meens Jochen, Gerlach Gerald-F

机构信息

Institut für Mikrobiologie, Zentrum für Infektionsmedizin, Stiftung Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.

出版信息

Infect Immun. 2005 Jun;73(6):3740-4. doi: 10.1128/IAI.73.6.3740-3744.2005.

DOI:10.1128/IAI.73.6.3740-3744.2005

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111875/

Abstract

In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.

摘要

为了研究铁摄取调节蛋白Fur在猪肺病原体胸膜肺炎放线杆菌中的作用，我们构建了一个基因内框缺失突变体——胸膜肺炎放线杆菌Δfur。该突变体表现出转铁蛋白结合蛋白的组成型表达、体外生长缺陷以及在气溶胶感染模型中的毒力降低。