铁摄取调节蛋白Fur的缺失会损害胸膜肺炎放线杆菌的体外生长和毒力。
Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.
作者信息
Jacobsen Ilse, Gerstenberger Jörg, Gruber Achim D, Bossé Janine T, Langford Paul R, Hennig-Pauka Isabel, Meens Jochen, Gerlach Gerald-F
机构信息
Institut für Mikrobiologie, Zentrum für Infektionsmedizin, Stiftung Tierärztliche Hochschule Hannover, Bischofsholer Damm 15, 30173 Hannover, Germany.
出版信息
Infect Immun. 2005 Jun;73(6):3740-4. doi: 10.1128/IAI.73.6.3740-3744.2005.
Abstract
In order to investigate the role of the ferric uptake regulator Fur in the porcine lung pathogen Actinobacillus pleuropneumoniae, we constructed an isogenic in-frame deletion mutant, A. pleuropneumoniae Deltafur. This mutant showed constitutive expression of transferrin-binding proteins, growth deficiencies in vitro, and reduced virulence in an aerosol infection model.
摘要
为了研究铁摄取调节蛋白Fur在猪肺病原体胸膜肺炎放线杆菌中的作用，我们构建了一个基因内框缺失突变体——胸膜肺炎放线杆菌Δfur。该突变体表现出转铁蛋白结合蛋白的组成型表达、体外生长缺陷以及在气溶胶感染模型中的毒力降低。
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