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A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.在兔心内膜炎模型中，rot突变可使无agr基因的金黄色葡萄球菌菌株恢复亲本毒力。
Infect Immun. 2005 Jun;73(6):3806-9. doi: 10.1128/IAI.73.6.3806-3809.2005.
2
Coordinated and differential control of aureolysin (aur) and serine protease (sspA) transcription in Staphylococcus aureus by sarA, rot and agr (RNAIII).金黄色葡萄球菌中sarA、rot和agr（RNAIII）对金黄色葡萄球菌溶血素（aur）和丝氨酸蛋白酶（sspA）转录的协同和差异调控
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3
Global virulence regulation in Staphylococcus aureus: pinpointing the roles of ClpP and ClpX in the sar/agr regulatory network.金黄色葡萄球菌的全局毒力调控：明确ClpP和ClpX在sar/agr调控网络中的作用
Infect Immun. 2005 Dec;73(12):8100-8. doi: 10.1128/IAI.73.12.8100-8108.2005.
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Inactivation of traP has no effect on the agr quorum-sensing system or virulence of Staphylococcus aureus.traP 的失活对金黄色葡萄球菌的 agr 群体感应系统或毒力没有影响。
Infect Immun. 2007 Sep;75(9):4519-27. doi: 10.1128/IAI.00491-07. Epub 2007 Jun 4.
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Regulation of Staphylococcus aureus type 5 capsular polysaccharides by agr and sarA in vitro and in an experimental endocarditis model.agr和sarA在体外及实验性心内膜炎模型中对金黄色葡萄球菌5型荚膜多糖的调控
Microb Pathog. 2002 Aug;33(2):73-9. doi: 10.1006/mpat.2002.0513.
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Global regulation of Staphylococcus aureus genes by Rot.Rot对金黄色葡萄球菌基因的全局调控
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7
Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis.金黄色葡萄球菌纽曼菌株中sarA和agr对纤连蛋白结合蛋白A基因表达及体外和实验性感染性心内膜炎中纤连蛋白黏附能力的影响
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Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis.葡萄球菌辅助调节因子（sar）与Agr协同作用，有助于金黄色葡萄球菌在眼内炎中发挥毒力。
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Hyperproduction of alpha-toxin by Staphylococcus aureus results in paradoxically reduced virulence in experimental endocarditis: a host defense role for platelet microbicidal proteins.金黄色葡萄球菌α-毒素的过度产生在实验性心内膜炎中导致毒力反常降低：血小板杀菌蛋白的宿主防御作用
Infect Immun. 1997 Nov;65(11):4652-60. doi: 10.1128/iai.65.11.4652-4660.1997.
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Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.临床金黄色葡萄球菌菌株在昆虫毒力模型中的Agr干扰。
J Bacteriol. 2006 Nov;188(21):7686-8. doi: 10.1128/JB.00700-06. Epub 2006 Aug 25.

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Regulation of Virulence.毒力调控
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Rot is a key regulator of Staphylococcus aureus biofilm formation.Rot是金黄色葡萄球菌生物膜形成的关键调节因子。
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3
Structure-based functional characterization of repressor of toxin (Rot), a central regulator of Staphylococcus aureus virulence.基于结构的金黄色葡萄球菌毒力核心调节因子毒素抑制因子（Rot）的功能表征
J Bacteriol. 2015 Jan 1;197(1):188-200. doi: 10.1128/JB.02317-14. Epub 2014 Oct 20.
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Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element.一株耐甲氧西林金黄色葡萄球菌（MRSA）克隆通过获得一个转座元件而产生高毒力的进化过程。
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Rot and SaeRS cooperate to activate expression of the staphylococcal superantigen-like exoproteins.腐烂和 SaeRS 合作激活葡萄球菌超抗原样外蛋白的表达。
J Bacteriol. 2012 Aug;194(16):4355-65. doi: 10.1128/JB.00706-12. Epub 2012 Jun 8.
7
Staphylococcus aureus leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth in vivo.金黄色葡萄球菌白细胞毒素 ED 通过靶向中性粒细胞和促进体内细菌生长来导致全身感染。
Mol Microbiol. 2012 Jan;83(2):423-35. doi: 10.1111/j.1365-2958.2011.07942.x. Epub 2011 Dec 20.
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Relationship of agr expression and function with virulence and vancomycin treatment outcomes in experimental endocarditis due to methicillin-resistant Staphylococcus aureus.实验性耐甲氧西林金黄色葡萄球菌心内膜炎中 agr 表达和功能与毒力及万古霉素治疗结果的关系。
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9
Rot and Agr system modulate fibrinogen-binding ability mainly by regulating clfB expression in Staphylococcus aureus NCTC8325.腐生葡萄球菌和葡萄球菌 aureus NCTC8325 调节 clfB 表达主要通过调控纤维蛋白原结合能力。
Med Microbiol Immunol. 2012 Feb;201(1):81-92. doi: 10.1007/s00430-011-0208-z. Epub 2011 Jun 24.
10
Staphylococcus aureus regulates the expression and production of the staphylococcal superantigen-like secreted proteins in a Rot-dependent manner.金黄色葡萄球菌以 Rot 依赖性方式调节葡萄球菌超抗原样分泌蛋白的表达和产生。
Mol Microbiol. 2011 Aug;81(3):659-75. doi: 10.1111/j.1365-2958.2011.07720.x. Epub 2011 Jun 16.

本文引用的文献

1
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.与23S rRNA基因中T2500A突变及单拷贝rRNA缺失相关的金黄色葡萄球菌连续分离株中的利奈唑胺耐药性
J Infect Dis. 2004 Jul 15;190(2):311-7. doi: 10.1086/421471. Epub 2004 Jun 9.
2
Oxazolidinones: activity, mode of action, and mechanism of resistance.恶唑烷酮类：活性、作用方式及耐药机制。
Int J Antimicrob Agents. 2004 Feb;23(2):113-9. doi: 10.1016/j.ijantimicag.2003.11.003.
3
Impacts of sarA and agr in Staphylococcus aureus strain Newman on fibronectin-binding protein A gene expression and fibronectin adherence capacity in vitro and in experimental infective endocarditis.金黄色葡萄球菌纽曼菌株中sarA和agr对纤连蛋白结合蛋白A基因表达及体外和实验性感染性心内膜炎中纤连蛋白黏附能力的影响
Infect Immun. 2004 Mar;72(3):1832-6. doi: 10.1128/IAI.72.3.1832-1836.2004.
4
An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria.一种工程化多结构域杀菌肽作为针对特定细菌的靶向抗生素模型。
Nat Biotechnol. 2003 Dec;21(12):1480-5. doi: 10.1038/nbt913. Epub 2003 Nov 16.
5
Characterization of RAP, a quorum sensing activator of Staphylococcus aureus.金黄色葡萄球菌群体感应激活剂RAP的特性分析
FEMS Microbiol Lett. 2003 Jun 27;223(2):167-75. doi: 10.1016/S0378-1097(03)00326-4.
6
Autoinduction and signal transduction in the regulation of staphylococcal virulence.葡萄球菌毒力调节中的自诱导和信号转导
Mol Microbiol. 2003 Jun;48(6):1429-49. doi: 10.1046/j.1365-2958.2003.03526.x.
7
Have the oxazolidinones lived up to their billing? Future perspectives for this antibacterial class.恶唑烷酮类药物是否名副其实？该抗菌药物类别的未来展望。
Curr Opin Investig Drugs. 2003 Feb;4(2):149-55.
8
Global regulation of Staphylococcus aureus genes by Rot.Rot对金黄色葡萄球菌基因的全局调控
J Bacteriol. 2003 Jan;185(2):610-9. doi: 10.1128/JB.185.2.610-619.2003.
9
Functional blocking of Staphylococcus aureus adhesins following growth in ex vivo media.在体外培养基中生长后金黄色葡萄球菌黏附素的功能阻断
Infect Immun. 2002 Oct;70(10):5339-45. doi: 10.1128/IAI.70.10.5339-5345.2002.
10
Global regulation of virulence determinants in Staphylococcus aureus by the SarA protein family.SarA蛋白家族对金黄色葡萄球菌毒力决定因素的全局调控
Front Biosci. 2002 Aug 1;7:d1825-42. doi: 10.2741/A882.

在兔心内膜炎模型中，rot突变可使无agr基因的金黄色葡萄球菌菌株恢复亲本毒力。

A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.

作者信息

McNamara Peter J, Bayer Arnold S

机构信息

Department of Medical Microbiology & Immunology, 1300 University Avenue, University of Wisconsin, Biochemistry Building, Room 250, Madison, WI 53706, USA.

出版信息

Infect Immun. 2005 Jun;73(6):3806-9. doi: 10.1128/IAI.73.6.3806-3809.2005.

DOI:10.1128/IAI.73.6.3806-3809.2005
PMID:15908418
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1111829/
Abstract

Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.

摘要

rot基因的突变可使金黄色葡萄球菌的agr阴性菌株恢复体外毒素产生能力。我们发现，在实验性心内膜炎感染中，通过靶器官细菌计数测量，rot基因突变可使agr突变体恢复野生型毒力。我们从agr拮抗剂策略的角度讨论了这些数据的意义。