在兔心内膜炎模型中，rot突变可使无agr基因的金黄色葡萄球菌菌株恢复亲本毒力。
A rot mutation restores parental virulence to an agr-null Staphylococcus aureus strain in a rabbit model of endocarditis.
作者信息
McNamara Peter J, Bayer Arnold S
机构信息
Department of Medical Microbiology & Immunology, 1300 University Avenue, University of Wisconsin, Biochemistry Building, Room 250, Madison, WI 53706, USA.
出版信息
Infect Immun. 2005 Jun;73(6):3806-9. doi: 10.1128/IAI.73.6.3806-3809.2005.
Abstract
Mutations in rot restore in vitro toxin production to agr-negative strains of Staphylococcus aureus. We show that a rot mutation returns wild-type virulence to an agr mutant, as measured in experimental endocarditis infections by target organ bacterial counts. Implications of our data are discussed in terms of agr antagonist strategies.
摘要
rot基因的突变可使金黄色葡萄球菌的agr阴性菌株恢复体外毒素产生能力。我们发现，在实验性心内膜炎感染中，通过靶器官细菌计数测量，rot基因突变可使agr突变体恢复野生型毒力。我们从agr拮抗剂策略的角度讨论了这些数据的意义。
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