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临床金黄色葡萄球菌菌株在昆虫毒力模型中的Agr干扰。

Agr interference between clinical Staphylococcus aureus strains in an insect model of virulence.

作者信息

Fleming Vicki, Feil Ed, Sewell Andrew K, Day Nicholas, Buckling Angus, Massey Ruth C

机构信息

Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

出版信息

J Bacteriol. 2006 Nov;188(21):7686-8. doi: 10.1128/JB.00700-06. Epub 2006 Aug 25.

DOI:10.1128/JB.00700-06
PMID:16936013
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1636260/
Abstract

Repression of virulence by Staphylococcus aureus strains from different Agr groups has been demonstrated in vitro and is proposed as a means of competitive interference. Here, using the insect Manduca sexta, we show for the first time that this interference also occurs in vivo within a mixed population.

摘要

来自不同Agr组的金黄色葡萄球菌菌株对毒力的抑制已在体外得到证实，并被认为是一种竞争性干扰手段。在此，我们利用烟草天蛾首次证明这种干扰在混合群体的体内也会发生。

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本文引用的文献

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2
Quorum-sensing control in Staphylococci -- a target for antimicrobial drug therapy?葡萄球菌中的群体感应控制——抗菌药物治疗的靶点？
FEMS Microbiol Lett. 2004 Dec 15;241(2):135-41. doi: 10.1016/j.femsle.2004.11.016.
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Peptide signaling in Staphylococcus aureus and other Gram-positive bacteria.金黄色葡萄球菌及其他革兰氏阳性菌中的肽信号传导
Peptides. 2004 Sep;25(9):1389-403. doi: 10.1016/j.peptides.2003.11.026.
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agr-dependent bacterial interference has no impact on long-term colonization of Staphylococcus aureus during persistent airway infection of cystic fibrosis patients.在囊性纤维化患者持续性气道感染期间，基于群体感应调节的细菌干扰对金黄色葡萄球菌的长期定植没有影响。
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