Rajenderkumar D, Bamiou D-E, Sirimanna T
Department of Audiological Medicine, Great Ormond Street Children's Hospital, Great Ormond Street, London, UK.
Arch Dis Child. 2005 Jun;90(6):592-3. doi: 10.1136/adc.2004.067298.
Apert syndrome is one of the craniosynostosis syndromes and is commonly associated with conductive hearing loss, but there are contradicting reports regarding the cause. Retrospective analysis of case notes of Apert syndrome patients seen between 1970 and 2003 was therefore undertaken. Seventy case notes were obtained; 59% were males. The incidence of congenital hearing impairment was 3-6%. Almost all had otitis media with effusion, which tends to persist into adulthood. More than 56% developed permanent low frequency conductive hearing loss by 10-20 years of age.
阿佩尔综合征是颅缝早闭综合征之一，通常与传导性听力损失有关，但关于其病因的报道相互矛盾。因此，对1970年至2003年间诊治的阿佩尔综合征患者的病历进行了回顾性分析。共获取了70份病历；其中59%为男性。先天性听力障碍的发生率为3%至6%。几乎所有患者都有中耳积液，且这种情况往往会持续到成年。超过56%的患者在10至20岁时出现永久性低频传导性听力损失。
