Fuchs Serge Y
Department of Animal Biology, University of Pennsylvania, Philadelphia, PA 19104-6046, USA.
Cancer Biol Ther. 2005 May;4(5):506-8. doi: 10.4161/cbt.4.5.1703. Epub 2005 May 5.
The F-box protein Fbw7/Sel-10/hCdc4/Ago, which is known to regulate ubiquitination and degradation of numerous important regulators of cell division and death including Notch, cyclin E, c-Jun and c-Myc, has been recently rediscovered as a p53-dependent tumor suppressor. Delineation of the mechanisms of Fbw7 anti-oncogenic activities and of its inactivation in human cancers is expected to gain an important insight into tumorigenesis.
F-box蛋白Fbw7/Sel-10/hCdc4/Ago，已知其可调节包括Notch、细胞周期蛋白E、c-Jun和c-Myc在内的众多细胞分裂和死亡重要调节因子的泛素化和降解，最近被重新发现为一种p53依赖性肿瘤抑制因子。阐明Fbw7的抗癌活性机制及其在人类癌症中的失活情况，有望为肿瘤发生提供重要见解。
