对完整蛋白激酶基因家族的筛查揭示了人类乳腺癌中体细胞突变的多样模式。
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.
作者信息
Stephens Philip, Edkins Sarah, Davies Helen, Greenman Chris, Cox Charles, Hunter Chris, Bignell Graham, Teague Jon, Smith Raffaella, Stevens Claire, O'Meara Sarah, Parker Adrian, Tarpey Patrick, Avis Tim, Barthorpe Andy, Brackenbury Lisa, Buck Gemma, Butler Adam, Clements Jody, Cole Jennifer, Dicks Ed, Edwards Ken, Forbes Simon, Gorton Matthew, Gray Kristian, Halliday Kelly, Harrison Rachel, Hills Katy, Hinton Jonathon, Jones David, Kosmidou Vivienne, Laman Ross, Lugg Richard, Menzies Andrew, Perry Janet, Petty Robert, Raine Keiran, Shepherd Rebecca, Small Alexandra, Solomon Helen, Stephens Yvonne, Tofts Calli, Varian Jennifer, Webb Anthony, West Sofie, Widaa Sara, Yates Andrew, Brasseur Francis, Cooper Colin S, Flanagan Adrienne M, Green Anthony, Knowles Maggie, Leung Suet Y, Looijenga Leendert H J, Malkowicz Bruce, Pierotti Marco A, Teh Bin, Yuen Siu T, Nicholson Andrew G, Lakhani Sunil, Easton Douglas F, Weber Barbara L, Stratton Michael R, Futreal P Andrew, Wooster Richard
机构信息
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
出版信息
Nat Genet. 2005 Jun;37(6):590-2. doi: 10.1038/ng1571. Epub 2005 May 22.
We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no somatic mutations. But a few had numerous somatic mutations with distinctive patterns indicative of either a mutator phenotype or a past exposure.
我们检测了25例乳腺癌中518种蛋白激酶的编码序列，每个样本的DNA约为1.3兆碱基。在许多肿瘤中，我们未检测到体细胞突变。但有少数肿瘤存在大量体细胞突变，其独特模式表明存在突变体表型或既往暴露史。
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