高剂量米索前列醇用于孕早期自然流产的门诊处理。
High-dose misoprostol used in outpatient management of first trimester spontaneous abortion.
作者信息
Sifakis Stavros, Angelakis Emmanuel, Vardaki Elpida, Fragouli Yvoni, Koumantakis Eugenios
机构信息
Department of Obstetrics and Gynecology, University of Crete, 71201 Voutes, Heraklion, Crete, Greece.
出版信息
Arch Gynecol Obstet. 2005 Sep;272(3):183-6. doi: 10.1007/s00404-004-0697-8. Epub 2005 May 21.
AIM
The aim of this study was to evaluate the efficacy and tolerance of a high dose of vaginal misoprostol for outpatient medical management of missed abortion.
METHODS
Three doses of 400 mug misoprostol were administered intravaginally every 4 h daily, for a maximum period of 3 days, to 108 women with uneventful first trimester pregnancy failure.
RESULTS
A total of 98 women (90.7%) were managed successfully, with 74 (68.5%) of them within the first 24 h. The mean dose of misoprostol administered was 1,113.0 microg (range 400-3,600 microg), and the mean time required was 19.5 h (range 7-65 h). Only 6 out of 108 women (9.3%) required surgical intervention as the result of retained products of conception. The side effect profile was minimal.
CONCLUSION
This protocol of 400 mug intravaginally misoprostol every 4 h as three daily doses for a maximum of 3 days, may offer an efficacious and safe alternative to the outpatient management of first-trimester missed abortion.
目的
本研究旨在评估高剂量阴道米索前列醇用于稽留流产门诊药物治疗的疗效和耐受性。
方法
对108例孕早期妊娠自然终止且情况平稳的女性，每天每4小时经阴道给予三剂400μg米索前列醇，最长持续3天。
结果
共有98例女性（90.7%）治疗成功，其中74例（68.5%）在24小时内成功。米索前列醇的平均给药剂量为1113.0μg（范围400 - 3600μg），平均所需时间为19.5小时（范围7 - 65小时）。108例女性中只有6例（9.3%）因妊娠物残留需要手术干预。副作用轻微。
结论
每4小时经阴道给予400μg米索前列醇，每天三次，最多持续3天的方案，可能为孕早期稽留流产的门诊治疗提供一种有效且安全的替代方法。
Zotero 插件