[低氧适应对大鼠心肌总蛋白、丙二醛和一氧化氮含量的影响]
[Effects of hypoxic acclimatization on myocardial contents of total protein, malondialdehyde and nitric oxide in rats].
作者信息
Long Chao-liang, Yin Zhao-yun, Wang Hai
机构信息
Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing, China.
出版信息
Space Med Med Eng (Beijing). 2004 Apr;17(2):114-6.
OBJECTIVE
To study the effects of acute hypoxia and acute hypoxia after intermittent hypoxic acclimatization on myocardial contents of total protein, malondialdehyde (MDA) and nitric oxide (NO) in rats.
METHOD
Myocardial contents of total protein, MDA and NO were investigated in rats after intermittent hypoxic acclimatization (simulated high altitude 3000 m and 5000 m, 4 h/d, 2 weeks respectively) and normal rats after they were exposed to hypoxia (simulated high altitude 8000 m) for 4 h.
RESULT
Compared with normal control rats, the myocardial contents of total protein and NO in acute hypoxic rats were reduced significantly, and the myocardial content of MDA was increased significantly. After intermittent hypoxic acclimatization, the myocardial contents of total protein and NO of rats were significantly higher and the myocardial content of MDA was significantly lower compared with those in acute hypoxic rats.
CONCLUSION
After intermittent hypoxic acclimatization, the myocardial contents of total protein and NO of rats were increased significantly and the content of myocardial MDA was decreased significantly. This is one of the biochemical mechanisms of hypoxic acclimatization of the heart.
目的
研究急性缺氧以及间歇性低氧习服后急性缺氧对大鼠心肌总蛋白、丙二醛（MDA）和一氧化氮（NO）含量的影响。
方法
对间歇性低氧习服（分别模拟海拔3000米和5000米，每天4小时，共2周）后的大鼠以及正常大鼠进行4小时缺氧（模拟海拔8000米）处理，然后检测大鼠心肌总蛋白、MDA和NO的含量。
结果
与正常对照大鼠相比，急性缺氧大鼠心肌总蛋白和NO含量显著降低，MDA含量显著升高。间歇性低氧习服后，与急性缺氧大鼠相比，大鼠心肌总蛋白和NO含量显著升高，MDA含量显著降低。
结论
间歇性低氧习服后，大鼠心肌总蛋白和NO含量显著增加，心肌MDA含量显著降低。这是心脏低氧习服的生化机制之一。
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