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[硒:生物学作用与抗氧化活性]

[Selenium: the biological role and antioxidant activity].

作者信息

Baraboĭ V A, Shestakova E N

出版信息

Ukr Biokhim Zh (1999). 2004 Jan-Feb;76(1):23-32.

Abstract

Selenium is essential trace element, sulphur analogue with high chemical activity, component of some selenoproteins and enzymes: glutathione peroxidase and other peroxidases, blood and tissue proteins. As to their biological action mechanism selenium and its compounds are antioxidants. Selenium is active immunomodulator, much more potent anti-oxidant than vitamins E, C and A, beta-carotene, but much more toxic. It takes part in thyroxine conversion to triiodethyronine in thyroid hormone biosynthesis. As sperm antioxidant selenium protected its motility and fertility. Selenium is a serious factor of biological and antioxidant protection of vascular endothelium, of low-density lipoproteins, protection of DNA, chromosomes. As food component selenium is an exceptional agent of protection from atherosclerosis, coronary ischemic disease and cancer. Some hydrobionts, liver, kidney, meal, corn and garlic, onion, cabbage, broccoli are dietary products with high content of selenium.

摘要

硒是一种必需的微量元素,是具有高化学活性的硫类似物,是一些硒蛋白和酶(如谷胱甘肽过氧化物酶和其他过氧化物酶、血液和组织蛋白)的组成成分。就其生物作用机制而言,硒及其化合物是抗氧化剂。硒是一种活性免疫调节剂,其抗氧化能力比维生素E、C和A、β-胡萝卜素强得多,但毒性也大得多。它参与甲状腺激素生物合成过程中甲状腺素向三碘甲状腺原氨酸的转化。作为精子抗氧化剂,硒可保护精子的活力和生育能力。硒是血管内皮、低密度脂蛋白生物和抗氧化保护以及DNA、染色体保护的重要因素。作为食物成分,硒是预防动脉粥样硬化、冠状动脉缺血性疾病和癌症的特殊保护剂。一些水生生物、肝脏、肾脏、肉类、玉米以及大蒜、洋葱、卷心菜、西兰花都是富含硒的食物。

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