Cameron J, Hoffman D, Wilson J, Cherry G
Department of Dermatology, Oxford Radcliffe Hospitals NHS Trust, Oxford, UK.
J Wound Care. 2005 May;14(5):233-6. doi: 10.12968/jowc.2005.14.5.26779.
A randomised controlled trial was designed to determine whether or not early intervention with a suitable skin barrier preparation could prevent skin breakdown. This study was conducted to compare the efficacy and cost-effectivenss of two skin protectants, Cavilon No Sting Barrier Film (NSBF) (3M Health Care) and zinc paste compound, in the management of maceration and irritation of the peri-wound area of venous leg ulcers.
Thirty-five patients with venous leg ulcers and surrounding skin problems were randomised to receive either NSBF or zinc paste compound. The preparation was then applied at each dressing change for 12 weeks. All patients had been receiving compression bandaging before entering the study and continued wearing it throughout the 12-week study period.
The decrease in wound area was 5.11+/-8.39cm2 in the NSBF group and 4.59+/-5.83cm2 in the zinc paste group. The healing rate was 0.046cm per week with NSBF and 0.039cm per week with zinc paste. There was a significant difference in the time required to remove and re-apply the skin protectants: an average of 0.19 (+/-0.17) minutes in the NSBF group and 5.53 (+/-2.10) minutes in the zinc paste group (p<0.0001).
Both products were effective barrier preparations. However, NSBF was easy to apply and transparent. The zinc paste was messy to apply and difficult to remove, and thus took up considerably more nursing time than NSBF.
This study was supported by 3M Health Care.
设计一项随机对照试验，以确定使用合适的皮肤屏障制剂进行早期干预是否可以预防皮肤破损。本研究旨在比较两种皮肤保护剂，即 Cavilon 无刺痛屏障膜（NSBF）（3M 医疗保健公司）和复方锌糊剂，在处理下肢静脉溃疡周围皮肤浸渍和刺激方面的疗效和成本效益。
35 例患有下肢静脉溃疡及周围皮肤问题的患者被随机分为两组，分别接受 NSBF 或复方锌糊剂治疗。然后在每次换药时使用该制剂，持续 12 周。所有患者在进入研究前均已接受加压包扎，并在整个 12 周的研究期间持续使用。
NSBF 组伤口面积减少了 5.11±8.39cm²，复方锌糊剂组减少了 4.59±5.83cm²。NSBF 组的愈合速度为每周 0.046cm，复方锌糊剂组为每周 0.039cm。去除和重新涂抹皮肤保护剂所需的时间存在显著差异：NSBF 组平均为 0.19（±0.17）分钟，复方锌糊剂组为 5.53（±2.10）分钟（p<0.0001）。
两种产品都是有效的屏障制剂。然而，NSBF 易于涂抹且呈透明状。复方锌糊剂涂抹时 messy（此处原文有误，可能是“messy”，意为“脏乱的”），难以去除，因此比 NSBF 占用了更多的护理时间。
本研究由 3M 医疗保健公司资助。
