Means L W, Fernandez T J
Department of Psychology, East Carolina University, Greenville 27858.
Behav Neurosci. 1992 Apr;106(2):345-50. doi: 10.1037//0735-7044.106.2.345.
In an experiment that compared 3 versions of a working memory task, male C57BL/6 mice given either 3 (n = 7) or 5 (n = 7) opportunities (test runs) per trial to choose the escape choice section of a maze acquired a win-stay (spatial matching-to-sample) water-escape task. Mice given only 1 test run per trial (n = 6) were unable to perform above chance level. In a 2nd experiment, 14 mice from the 1st experiment were tested for performance on the 3-test-run version of the task. Each mouse was tested for 12 consecutive days with each of 4 doses of glucose (0, 50, 100, & 250 mg/kg ip) given 30 min before testing. The two higher doses increased the percentage of correct test run choices on all 3 daily test runs across the 12 days of testing. Daily glucose injections facilitated the use of trial-dependent information.
在一项比较工作记忆任务的3个版本的实验中，每次试验给予雄性C57BL/6小鼠3次（n = 7）或5次（n = 7）机会（测试运行）以选择迷宫的逃生选择区域，这些小鼠学会了一种赢则停留（空间匹配样本）的水迷宫任务。每次试验仅给予1次测试运行的小鼠（n = 6）无法表现出高于随机水平的成绩。在第二个实验中，对来自第一个实验的14只小鼠进行了该任务的3次测试运行版本的性能测试。在测试前30分钟，给每只小鼠连续12天每天测试4种剂量的葡萄糖（0、50、100和250mg/kg腹腔注射）中的一种。在整个12天的测试中，两种较高剂量增加了所有3次每日测试运行中正确测试运行选择的百分比。每日注射葡萄糖促进了对试验相关信息的利用。
